Archive for 2010

The Paper

December 5th, 2010

I’ve been working with Rob Ashe to start a newspaper–The Paper. Our first publication will come out in January, 2011. Click on Rob’s picture to watch a video about our mission–or read our letter below.

Rob Ashe, Founder and Publisher of The Paper

We are a different newspaper. In a positive way. Not a fluffy positive way, but a meaningful, real way. There are a lot of great people and things happening in Menlo Park, Woodside, Portola Valley, and Atherton that we think deserve attention. We want to be a voice that highlights the good, significant, and meaningful parts of our community.

We don’t want to print yesterday’s news. Our articles and photos are timeless; meaningful stories that will be relevant for a long time.

Our stories are inspiring, but sometimes they might be challenging. We will highlight the role models in our community–the people that we want to be more like. We don’t want to fill your heads with gossip or depressing news; there is enough of that. Much of the current news features the worst events that happen in our community. Of course it gets our attention, but through fear.

We’ve found that what’s most meaningful in our lives is when we stop thinking of ourselves. Focusing on others and what’s right with the world feels more significant and purposeful. We forget this easily though, and need a constant reminder. The Paper is that reminder–that righteous kick in the ass, or if you prefer the less vulgar; the angel on your shoulder.

Maybe you’re happy with where you are, and how things are going. That’s wonderful. But we know a lot of people that want more. We believe in our community, but think that we can be even better. We have the privilege of being one of the most innovative, trendy, and wealthy communities in the world. At The Paper, we want to encourage the use of our influence for the betterment of our own community, and those that look up to us.

We don’t have the answers, but know we can come up with them together, as a community. Let’s talk about critical issues and ask the questions that need to be asked. Let’s inspire the world, starting with ourselves.

I’m Back with Medical Posts from Mexico

October 16th, 2010

You might be wondering where I’ve been and why I haven’t posted since May…

I’ve been in a cultural, language, and rain immersion “program” in Oaxaca, Mexico since June. Unfortunately, the program doesn’t come with reliable internet.

The next few posts will be of the medical anthropology sort. In addition to learning Spanish and how to hang-dry laundry during the rainy season, I have also had the opportunity to compare and contrast medical practices between the United States and Mexico. The first post is about the widespread use of syringes for medication administration in Mexico.

Luckily, I have not had the experience of using my airlift insurance yet, however. In my recently published article,“Will Health Insurance Cover You Overseas?” I have some health insurance recommendations for travelers–such as purchasing airlift insurance.

Medical Lesson from Mexico: Use of Intramuscular NSAIDs for Autoimmune Diseases

October 16th, 2010

One important difference I have seen in Mexican medicine is the widespread use of intramuscular medications (IMs). In large numbers doctors prescribe many medications, from antibiotics to non-steroidal anti-inflammatories (NSAIDs) in IM form rather than oral (pill) form.

I asked a rheumatologist in Oaxaca why he often used intramuscular NSAIDs for his patients with autoimmune diseases–his response: to protect the stomach. This is very important for patients with autoimmune diseases who are typically taking many other medications, such as prednisone, that wreak havoc on the intestines. Adding oral NSAIDs that are also processed via the stomach, only adds to the damage (both short-term discomfort and long-term complications).

Therefore, the idea of taking IM NSAIDs for pain and inflammation in autoimmune diseases seems novel, yet obvious.

So I wondered; Why haven’t doctors in the U.S. prescribe IMs more often? And particularly; why not NSAIDs for autoimmune patients?

Instead, rheumatologists in the U.S. prescribe large doses of oral NSAIDs, then have to prescribe other medications (like proton pump inhibitors) to treat stomach symptoms. Why not just avoid the stomach irritation in the first place by replacing oral NSAIDs with intramuscular NSAIDs?

The problem: SYRINGES

IM medications require syringes, and with a little digging I uncovered an alarming amount of problems associated with the widespread use of syringes.

Expense
Inconvenience (need to have someone else–preferably a trained professional–administer medication)
Complications at the injection site (pain, bruising, infection, hematoma, etc…)
Increased risk of disease transmission (sharing unsterilized needles)
Environmental contamination

Despite the potential advantage for some individuals, overall it seems that injectable medications are being dangerously overused in Mexico. That being said, I think this is just another example of the importance of anthropology in the medical world. Perhaps Mexican doctors and patients should curtail the use IM medications when unjustifiable, whereas U.S. doctors and patients can learn to use such a treatment in select cases, like NSAIDs for autoimmune patients, with proper administration.


Syringes in Mexico…

After a doctor’s appointment, patients are given a slip of paper with the name and dosage of the injectable medication.

That’s it.

No instructions on where to get the syringes, who should inject it, how to inject it, side effects, warnings, or how to properly dispose of the syringes. Nor do the pharmacies give the obligatory information sheets required in the U.S. Just provide a box of liquid medication. It is then your job to figure out how to get it into a syringe, then into your body.

Luckily the supermarkets have isles full of syringes, usually just next to the shampoo. You have your choice of a variety of sizes and brands. Once you purchase a box, again, you will not find any detailed instructions included. Just a simple 5-step process on the box–from washing your hands to putting pressure on the site afterward. And that’s it. About the same amount of instruction you will find for how to apply conditioner to your hair after shampooing. Scary.

Playing Games for Medical Innovation

May 28th, 2010

The Myelin Repair Foundation (MRF), a medical research organization developing treatments for multiple sclerosis, is incredibly innovative and has successfully challenged the way medical research is being done. Recently, the MRF received a grant from the Robert Wood Johnson Foundation to “organize two virtual forums to engage innovators both inside and outside the medical research field to explore ideas and strategies like the MRF model that could lead to more effective and efficient ways to fund and conduct research.”

The MRF is working with another Bay Area non-profit, the Institute for the Future in Palo Alto, CA (IFTF), to develop this virtual forum (or game). The game will use “crowd sourcing” technology to discuss solutions to problems that currently limit the development of patient treatments. The goal is to generate solutions to accelerate drug discovery and development in all areas of medical research, for all diseases, and all patients.

There three reasons why I think this will work:

First, playing a game unleashes creativity and other qualities not typically utilized in other problem setting situations. Secondly, an open-source environment promotes input from a broad group of people and perspectives.

And finally, the computing age was “hatched” in a similar way. In the May 2010 edition of Wired magazine author Steven Levy writes “I thought of hackers as little more than an interesting sub-culture. But as I researched them, I found that their playfulness, as well as their blithe disregard for what others said was impossible, led to the breakthroughs that would define the computing age.”  Furthermore, he states, “most of them did it simply for the job of pulling off an awesome trick.”

Doesn’t this sound a lot like playing a game? Twenty-five years ago Bill Gates and Steve Wozniak were not working for companies that told them what they had to achieve. Nor were their goals financial or market-driven. Clearly, Hackers shared many gamer qualities like “blissful productivity, “desire for epic meaning,” and the “urgent optimism” that Dr. Jane McGonigal of the ITFT observes in the gaming culture today.

I believe that creating a gaming environment is a potential way to facilitate breakthroughs on par with those of the computer hackers 25 years ago.

What do you think about gaming? Do you play yourself? Or if you have children, do you allow them to play?

I wrote a longer piece posted on MRF’s blog. You can read the entire blog entry here. Check back for details later this summer on how to participate.

Doctor’s New RX: Smoking?

April 29th, 2010

Conflicting medical advice seems to be more prevalent than ever. For instance, we now know that long-term use of aspirin can lead to deadly, internal bleeding. Just recently, though, reports about cardiac benefits were being touted and we were told that “one apple and an aspirin a day, keeps the doctor away.”

For years, fish continued to win the gold for healthiest food. But now we have to be weary of fish—and only eat certain types that are raised in certain places and are not contaminated with certain chemicals like mercury.

Smoking, since I was born, has always been considered one of the most detrimental habits. Almost everything you read about “being healthy” includes something about managing your weight and not smoking. It would be outrageous for a doctor to prescribe nicotine, or tell a patient to keep smoking.

Or would it?

I just returned from the ABDA (American Behcet’s Disease Association) Medical Conference in Orlando with a new perspective about smoking. My first clue that smoking might be pushing its way back into society should have been the extremely large number of the participants smoked. During breaks, instead of sitting inside checking email like most medical conference attendees, I found many of the patients outside in the hot Florida sun inhaling cigarettes.

Talking to patients outside I heard comments like, “I tried to stop smoking but my symptoms got worse.” Or, “My doctor doesn’t believe me, but I am so much healthier when I smoke.”

Then some of the non-smokers would chime in, “I know. I quit smoking and I’m trying to manage my symptoms with prescribed medications, but I still don’t feel as good.”

This was surprising to me, but not as shocking as the news that Dr. Yusuf Yazici, rheumatologist and researcher at NYU, presented during his lecture; “The Latest Treatments for Behcet’s Disease.”

Behcet’s disease is an autoimmune disease that results from damage to blood vessels throughout the body, particularly veins, and according to Dr. Yazici, “Nicotine patch therapy should be used more as a treatment.” He went on to discuss other new treatments for Behcet’s such as cytokine therapy and biologics as if there was nothing controversial about his earlier comment.

Can smoking really be good for your health?

There are many contradictions but few seem so paradoxical. Apparently the good side of this bad drug has been known for quite some time. Autoimmune disorders, like Behcet’s, are treated with immunosuppressants, of which nicotine is one. Logically, then, it would follow that nicotine would help. I wonder why this is “new” news then.

A 2004 study published in the Clinical and Diagnostic Laboratory Immunology concluded that “Tobacco smoking suppresses the immune system…Interestingly, smokers have a lower incidence of some diseases, including ulcerative colitis, sarcoidosis, endometriosis, uterine fibroids, farmers’ lung, pigeon breeders’ disease, Parkinson’s disease, and Sjögren’s syndrome. Many of these diseases are inflammatory in nature or have an inflammatory component.” (1)

Even though there is new, compelling evidence that nicotine therapy reduces symptoms of autoimmune diseases, like Behcet’s, we should know by now that nothing is that simple when it comes to your health (especially treating an autoimmune disease).

Do your research, and of course “talk to your doctor,” before running to the corner store for a pack of smokes if you think nicotine might benefit your condition, because limited knowledge is dangerous. Understanding all of the previous dietary and medicinal suggestions for your illness, for instance, can provide a framework and healthy skepticism for the newest health advice. Just like knowledge of history reveals that mistakes are often made, proving the benefit of discernment today and tomorrow.

History can also remind us that:

Many of the ingredients in a cigarette are still undeniably bad for the body. Thus, nicotine patches—not cigarettes themselves—are being suggested. See the 2004 paper published in the Journal of Investigative Dermatology, entitled, “Nicotine and Biochanin A, but Not Cigarette Smoke, Induce Anti-Inflammatory Effects on Keratinocytes and Endothelial Cells in Patients with Behçet’s Disease” for more information. (2)

We cannot assume that nicotine helps with all symptoms because “the efficacy in the treatment and prevention of other systemic manifestations of BD is not proven,” according to a recent study published in March 2010 in the Oxford Journal of Rheumatology. This study does conclude, though, that “Both smoking and nicotine-replacement therapy may be efficacious not only on oral aphthae, but also on other mucocutaneous manifestations”—major Behcet’s symptoms.

The research is still contradictory. For instance, Behcet’s is a type of vasculitis. Vasculitis simply means inflammation of the blood vessels. And therefore there is a logical argument stated on the website of Arthritis Research UK which says “Avoid smoking. It makes the blood vessels constrict (become narrower inside) and can therefore make vasculitis symptoms worse.”

References
(1) Immunosupprisive and anti-inflammatory effects of nicotine administered by patch in an animal model. Kalra R, Singh SP, Pena-Philippides JC, Langley RJ, Razani-Boroujerdi S, Sopori ML. Clinical and Diagnostic Laboratory Immunology, (2004) May; 11(3): 563-8.
(2) Nicotine and Biochanin A, but Not Cigarette Smoke, Induce Anti-Inflammatory Effects on Keratinocytes and Endothelial Cells in Patients with Behçet’s Disease. Aylin Kalayciyan, Helmut Orawa, Sabine Fimme, Frank H Persche, José-B González, Rudolf G Fitzner, Constantin E Orfanos, and Christos C Zouboulis. Journal of Investigative Dermatology, (2007) 127, 81–89.
(3) Nicotine-patch therapy on mucocutaneous lesions of Behcet’s disease: a case series. Ciancio G, Colina M, La Corte R, Lo Monaco A, De Leonardis F, Trotta F, Govoni M. Oxford Journal of Rheumatology, (2010) Mar; 49(3): 501-4.
Transdermal Nicotine for Active Ulcerative Colitis. Rupert D. Pullan, John Rhodes, Subramanian Ganesh, Venk Mani, John S. Morris, Geraint T. Williams, Robert G. Newcombie, Michael Russell, Colin Feyerabend, Gareth Thomas and Urbai Sawe. New England Journal of Medicine. (1994) Mar; 330:811-815.

More Reasons to Get Dirty (Hygiene Hypothesis)

March 26th, 2010

My first blog posts were about the interesting, and relatively new, idea that being too clean is bad for you. More specifically; the lack of exposure to germs and other infectious agents like parasites at a young age can cause serious, chronic health conditions later in life due to the improper development of the immune system.

I mentioned that this idea, the hygiene hypothesis, has become a plausible explanation for the high incidence of autoimmune and allergic diseases in the developed countries — as opposed to countries where lack of healthcare and sterile environments is typically seen as a problem. A study at Northwestern University led by Thom McDade, Ph.D. and an associate professor of anthropology, added proof to this theory. his results showed that too much hygiene can also result in cardiovascular problems as an adult. McDade’s evidence is based on levels of C-reactive proteins, which is a protein in the blood that increases as a result of inflammation. As I mentioned previously, inflammation and C-reactive protein levels are critical in autoimmune and allergic diseases, as well as cardiovascular diseases.

In the March 24, 2010 Chicago Tribune article, “NU Study: Dirt’s Good for Kids,” Dade is quoted as saying “there is such a thing as being too clean. The contrarian theory, known as the hygiene hypothesis, is gaining traction in some medical circles.”

Please read my first three blog entries and let me know your opinion on this topic!

Want to Lose Weight? Another Reason to “Yoga”

February 21st, 2010

In my last blog entry I discussed the benefits that yoga can have on inflammatory diseases, but was curious to see if there had been research documenting yoga’s effect on weight-loss.

There has. Perhaps the most sited study was lead by Dr. Alan Kristal, DPH, MPH at the Fred Hutchinson Cancer Research Center. The 2005 study, which included 15,500 people age 45-55, reported that yoga can help prevent weight gain.

But exactly how is still somewhat of a mystery. One theory suggests that the strong mind-body connection yoga develops, helps you become aware of what it feels like to be full — and therefore when to stop eating. Dr. Kristal’s slightly different opinion suggests that “regular yoga practice is associated with mindful eating…which helps change the relationship of mind to body, and eventually to food and eating.”

I find the most interesting and scientifically viable explanation that of Rebecca Brenner. She holds a Ph.D. in nutrition and is the owner of Park City Holistic Health in Utah. In a recent article published in Yoga Journal, which also cites Dr. Kristal’s study, Rebecca explains that yoga strengthens the digestive system — in addition to the muscles we typically think of when we hear the word strength.  “Digestive health is essential to all health,” states Rebecca. “It will affect the way you break down and assimilate food, vitamins and minerals. If you are not digesting properly, your body will trick you into cravings that can affect your weight loss.”

I also find it extremely interesting that when I was searching for research regarding the weight-loss benefits of yoga, I found an article quoting my cousin, Rebecca Brenner!

Exciting New Study at Ohio State University: Yoga Fights Inflammatory Diseases

February 20th, 2010

When you think of activities that are “good for you,” yoga is usually at the top of the list. I never stopped to wonder if this was true because I have heard it so many times and honestly it just seems to make sense. It seems natural that yoga is healthy for your body because we know that exercise which increases your heart rate is “good.” We also know that stretching your muscles is “good.” Yoga combines both of these, while adding the extra benefit of deep breathing.

In my yoga class last Saturday lead by Nanci Conniff (who teaches yoga to students and sports teams at Stanford), she mentioned a recent study at Ohio State University which proves the positive effects yoga has on inflammatory conditions. Nanci spends her career teaching Stanford athletes how to incorporate yoga into their training regimens — for both physical and mental benefits. I often laugh picturing 300lb football players doing the cat pose.

I’m always on the lookout for cutting-edge research which will help us lead healthier lives, so I looked up the study and want to spread the news. If we ever doubted yoga’s health benefits and used it as an excuse not to partake in the activity, we can’t run any longer!

Last month, Dr. Janice Kiecott-Glaser and her team at Ohio State University published a study which showed that regular yoga practice strongly reduces the amount of Interleukin-6 in our bodies (by 41% in their particular study). Cytokine Interleukin-6 plays a large role in our bodies inflammatory system. Too much, though, can lead to diseases such as stroke, type-2 diabetes, autoimmune conditions, and heart disease – to name a few.  This study proves that yoga allows us to regulate and reduce the production of Interleukin-6 in our bodies, thereby reducing chronic inflammation — and improving the quality of our lives! View the study published on PubMed.

The Mayo Clinic website published an article shortly after entitled: Yoga, Tap Into the Many Health Benefits

According to the article, yoga has the ability to reduce stress and increase fitness (not very surprising). Managment of chronic health conditions is also mentioned, perhaps as a result of the Ohio State study. I was surprised to read, though, that yoga can contribute to weight loss. It does not say how, exactly, just that “If you’re overweight or have binge-eating disorder, yoga may help you make the healthy lifestyle changes necessary to gain control of your eating and drop those extra pound.” Maybe this should be the next study…

Okay, no excuses for me this morning, I have twenty minutes to get to Yoga!

Final Thoughts About the Hygiene Hypothesis…and the Horrifying Treatment

February 16th, 2010

“Wash your hands before you eat.”

Sound familiar?

Perhaps washing our hands all of the time may not be such a great idea, if there is any truth to the hygiene hypothesis.

Like most people in the U.S., and other developed countries, I’ve been taught that germs are bad. I even read a book to my niece recently called, Germs Make Me Sick! (I’m not kidding, you can find it on Amazon for $5.99).

Since I was old enough to clean (which was pretty young in my family), we spent weekends waging war on germs in our own little microcosm of the world (our house). I learned how to spray and scrub the bathroom with all sorts of disinfectants, washed my clothes with extra-strength detergent, and scrubbed every little bit of food particle off of my dishes with antibacterial dishwashing soap.

Then, after all of that cleaning, I had to clean myself. I always spent an extra long time in the shower after a hard day of cleaning, just to make sure that I killed any of the bad germs that might have leapt onto me from my sponges or mops.

If you grew up in the U.S., you can probably relate to this.

Little has changed, actually. My shower is still my safe haven against germs (once it’s been scrubbed with Comet, of course). Like the products that reside under the kitchen and bathroom sinks, I have an equally vast pharmacy of cleansing products in my shower for myself: different kinds of cleansers for my face, hair, and body. And often numerous types for each part of my body — most accumulated out of boredom, really, while waiting 30-minutes at Walgreens for a prescription.

So, the idea that being too clean can make you sick is fascinating – and scary.

It’s extremely ironic to think that simply growing up in a developing country – with the “highest” medical care, and cleanliness, — can actually cause us to be grow up to be very sick. This radical idea the hygiene hypothesis proposes suggests that our habits of cleanliness, sterilization, vaccination and antibiotics may cure us from the common cold but can leave us fighting severe allergies or a devastating disease for the rest of our life.

Perhaps just as disturbing as the idea that we are getting sick from our efforts to avoid illness, is the treatment. In order to cure our lack of exposure to parasites and other infectious agents, hygiene theorists are testing cures by purposefully injecting people with the larvae of a parasitic worm (or helminth). This treatment, referred to as Helminthic therapy,has proved promising in research studies, the risks of severe side effects in some cases are too to become commonplace just yet.

I could probably get used to the idea of not showering or cleaning as much (okay, I could definitely get used to not cleaning), but I’m not sure I would be able to knowingly ingest parasites, like hookworms, into my body.

But…ironically, if this hypothesis holds true, what many of us in the industrialized world have been taught to fear, would be our cure.

So maybe the next time you ride the subway touch all of the poles. Then go home and take out the trash, making sure to adequately touch the lid of the trashcan. Next, scrub your toilet with the kitchen sponge. Then pick up some food you find on the floor (check under the oven or the refrigerator) and eat it. At no point should you wash your hands.

If someone looks at you in disgust, say, “Hey, I’m just trying not to get sick.”

What do you do now in order to prevent yourself from getting sick?

Would you change some habits if we found out that the hygiene hypothesis was true?

What would be the hardest “cleanliness” habit to break?

The Hygiene Hypothesis Continued: What Could this Mean?

February 13th, 2010

Considering humans lived with millions of  “germs” for hundreds of thousands of years, and it was not until the last few hundred that we decided to limit our exposure, it seems logical that we would see some physiological effects or changes from our new habits.  While researchers have agreed upon the idea that immunological diseases are much more prevalent in industrialized countries, they have not agreed upon the cause. The hygiene hypothesis, however, has not been close to the top of the list of plausible explanations.

For instance, it is more common to hear the theory that individuals are at a higher risk for developing an autoimmune disease in developing countries because of our northern latitude. Without as much sun at these latitudes, individuals are at risk for vitamin D deficiency, which has been linked to regulation of the immune system.

______

After six years at a medical research organization devoted to developing a treatment for an autoimmune disease, multiple sclerosis (MS), I thought I have heard every possible cause of such a disease. I have answered hundreds of “What causes MS?” questions with the same answer, “We don’t know what causes any autoimmune disease, but there is often a genetic predisposition and the actual disease (or diseases as some might argue) could be triggered by a virus, environmental factor, or both.”

I have also heard many anecdotal stories of how to cure the mysterious diseases from those outside the research community, like:

“My sister had rheumatoid arthritis and took Omega-3 oil and is completely fine now.”

Or, “My friend had MS and he knows that it was caused by heavy metal toxicity so he started taking silver is back to normal.”

Sometimes, people admitted that it wasn’t actually that simple to cure these complex diseases. It took their “friends” two things, like acupuncture and a gluten-free diet. Or moving to India and meditating everyday.

Okay, so maybe I’m being a little cynical, but I just find it hard to believe that these things could work for one person, but not for the millions of other people in the world suffering from the same disease. And trust me, if you have an autoimmune disease, you’ve probably tried every traditional and not-so-traditional way to “cure yourself” — from acupuncture to infusions of corticosteroids at your local E.R.

But even if someone is lucky enough to find a way to cure themselves, I am more interested in  prevention. Let’s stop the diseases before they start – so we don’t have to drink silver or move to India.

The hygiene hypothesis is radical, but if there is any truth to it, the implications of addressing this problem are enormous; we would be able to prevent chronic illness in hundreds of thousands of people in the U.S. alone.

–––––

I’m pleased to see this hypothesis growing in interest and credibility among the scientific community of immunologists, rheumatologists, and others in similar fields of researcher. Regardless of whether the hygiene hypothesis turns out to be the cause of autoimmune and allergic diseases, I think it is important to consider the affect of meddling with our body’s immune system.

Subscribing to the idea that over-cleansing, and under-burdening ourselves with germs, as the cause of our relatively high incidence of allergic and autoimmune diseases would have incredible implications.

It would mean that instead of popping a daily vitamin D pill, we would have to re-consider the way our society runs, from vaccinating children to using anti-bacterial cleansers.

It is a well-known concept that much of life operates on the idea of give and take. Trade-offs. Like drinking water in portable sized plastic bottles might be extremely convenient and hydrate our bodies in the short term, it might not be so great for the environment in the long term.

So, while the positive ramifications of our recent medical developments are noticeable and commendable — like the ability to end polio or typhoid fever — might there be a trade-off here too? Are we trading a cold for a chronic illness?

Do you believe the hypothesis might hold some truth? What could this mean for our future?